Table 2.
Phenotypic spectrum across the MEN syndromes. Abbreviation: CD, Cushing disease; MTC, Medullary Thyroid Carcinoma; NET, Neuroendocrine tumors; PHPT, primary hyperparathyroidism;PGL, paraganglioma; PTC, Papillary Thyroid Carcinoma.
| MEN Type |
Pituitary Tumors |
Acromegaly | CD | PHPT | MTC | PTC | Pheochromo cytoma |
PGL | Adrenal tumors |
Pancreatic NET |
Lung/Bronchial NET |
Gastric NET |
Thymic NET |
Gastrinoma | Skin |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| MEN1 | + | + | + | + | + | + | + | + | + | + | + | ||||
| MEN2A | + | + | + | + | + | ||||||||||
| MEN2B | + | + | + | + | + | ||||||||||
| MEN4 | + | + | + | + | * | ** | + | + | + | + | + |
*
A single case report of Cushing disease in a patient with MEN2B
**
A single case report of metastatic PTC in a patient with MEN4
***
Not yet found in humans