Table 1.
Major criteria | Minor criteria | Exclusion criteria |
---|---|---|
(A) Atypical presentation of opportunistic infection or tumors in patient responding to ART (B) Decrease in plasma HIV RNA level > 1 log 10 copies/ml |
(1) Increase in CD4+ T-cell count after ART (2) Increase in immune response specific to relevant pathogen (3) Spontaneous resolution of disease with no specific antimicrobial therapy or tumor chemotherapy while continuing ART |
(1) Failure of treatment to OIs because of microbial drug resistance (2) Poor adherence to treatment for OI/absorption problems (3) Presence of other OIs or neoplasm, drug toxicity, or reaction |
For IRIS diagnosis patients must meet 2 major criteria (A + B) or one major criterion (A or B) plus 2 minor criteria (1, 2, or 3), without the presence of exclusion criteria, IRIS immune reconstitution inflammatory syndrome, ART antiretroviral therapy, OIs opportunistic infections, and HIV human immunodeficiency virus.