Table 1. Summary of evidence by comparison investigated and study methodology.
Comparator | RCTs [ref] | NRSIs [ref] | Ongoing trials |
Choice of investigation | |||
Flexible sigmoidoscopy vs. CTA | None | None | |
Flexible sigmoidoscopy vs. other | None | None | |
Colonoscopy vs. CTA | None | Nagata 2015 26 Yabutani 2014 21 | |
Colonoscopy vs. other (e. g. standard care) | Green 2005 4 | Yamaguchi 2006 23 | |
CTA vs. other | None | Ketwaroo 2012 18 Sun 2011 20 Jacovides 2015 25 | |
Diagnostic mesenteric angiography vs. other | None | None | |
Timing of first-line investigation | |||
Colonoscopy: Early (< 24 hours) vs. late (> 24 hours) | Laine 2010 | Abeldawi 2014 24 Nagata 2016 27 Strate 2003 28 Rodriguez-Moranta 2007 19 | |
Radiology: A) Urgent CTA vs. nonurgent B) Urgent mesenteric angiography vs. nonurgent | None None | None None | |
Choice of treatment | |||
Therapeutic endoscopy vs. mesenteric embolization | None | None | |
Therapeutic endoscopy vs. other | None | Jensen 2000 30 | Matsuhashi JPRN-UMIN000008287 |
Embolization vs. other | None | None | |
Endoscopic agent A vs. B | None | Nakano 2015 22 Ishii 2011 17 | Barkun NCT02135627 |
RCT, randomized controlled trials; NRSI, nonrandomized studies of intervention; CTA, computed tomographic angiography.