Table 2. Interstudy variability of the definition of rebleeding.

Study [ref]	Definition of rebleeding
Green 2005 4	Hematochezia (defined as any one of > 3 bloody bowel movements in < 8 hours, ICU admission, > 5 % decrease in Hct in < 12 hours, transfusion of > 3 units RBC, hemodynamic instability in previous 6 hours defined as angina, syncope, pre-syncope, orthostatic vital signs, MAP < 80 mmHg or HR > 110) after clinical cessation of the index bleeding event
Laine 2010 29	Hematochezia persisting for > 24 hours, recurrent hematochezia after initial resolution (e. g. brown stool followed by hematochezia), HR > 100 or SBP < 100 mmHg after hemodynamic stability for ≥ 1 hour, or hemoglobin drop > 2 g/dL after stable hemoglobin values ≥ 3 hours apart
Nagata 2016 27	Significant amounts of fresh bloody or wine-colored stools after index colonoscopy with unstable vital signs; SBP ≤ 90 mmHg or HR ≥ 110 or the need for blood transfusion
Strate 2003 28	Blood per rectum after 24 hours of stability accompanied by a drop in Hct ≥ 20 %, and/or a requirement of additional blood transfusions
Abeldawi 2014 24	After clinical cessation of index bleeding event during hospitalization
Nagata 2015 26	Significant fresh bloody or wine-colored stool accompanied by unstable vital signs; SBP ≤ 90 mmHg or HR ≥ 110 and nonresponse to ≥ 2 units transfused blood
Jensen 2000 30	Self-limited or recurrent hematochezia that required no more than an additional 2 units of packed red cells or continued or recurrent hematochezia that required at least 3 units of packed red cells
Ishii 2011 17	Clinical evidence of recurrent bleeding

ICU, intensive care unit; Hct, hematocrit; RBC, red blood cells; MAP, mean arterial pressure; HR, heart rate; SBP, systolic blood pressure.