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. Author manuscript; available in PMC: 2018 Jul 12.
Published in final edited form as: J Am Chem Soc. 2017 Jul 3;139(27):9317–9324. doi: 10.1021/jacs.7b04583

Table 2.

Application of the bis-arylation reaction conditions in the synthesis of chiral bulky NHC ligands

graphic file with name nihms907604u3.jpg
entry R yield of 5a–d yield of 4a–d
1 graphic file with name nihms907604t1.jpg 5b, 78%a 4b, 79%
2 graphic file with name nihms907604t2.jpg 5a, 73% 4a, 97%
3 graphic file with name nihms907604t3.jpg 5c, 39% 4c, 55%
4 graphic file with name nihms907604t4.jpg 5d, 36% 4d, 57%
5 graphic file with name nihms907604t5.jpg not observed
6 graphic file with name nihms907604t6.jpg not observed
a

10 mmol scale and the product was isolated by recrystallization.