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. Author manuscript; available in PMC: 2018 Jul 12.
Published in final edited form as: J Am Chem Soc. 2017 Jul 3;139(27):9317–9324. doi: 10.1021/jacs.7b04583

Table 4.

Couplings involving methyl-substituted alkynes

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entry RL RS R temp (°C) rr yield (%) ee (%)
1 Cy Me t-BuMe2 rt >95:5 79 28
2 n-Pr Me t-BuMe2 rt3 >95:5 83 38
3 n-Pr Me i-Pr rt >95:5 74 11
4 n-Pr Me t-BuMe2 50 >95:5 78 38
5 n-Pr Me t-BuMe2 −20 >95:5 74 33
6 n-Pr Me t-BuMe2 −78 >95:5 70 32