Figure 1.

Treatment Schema: Early Favorable Hodgkin Lymphoma.

^aPatients without response should have a biopsy. If biopsy is positive, consider transitioning to a salvage regimen.

^bThis approach is based on the RAPID-UK study, but not a preferred approach. Patients with Deauville score of 4 to 5 should have a biopsy and consider transitioning to escalated BEACOPP if negative or a salvage regimen and autologous transplant if biopsy is positive.

^cRadiation with smaller fields, including involved site irradiation (ISRT) or involved nodal irradiation (INRT).

^dRadiation dose varies based on PET response and bulky versus nonbulky disease.

GHSG indicates German Hodgkin Study Group; EORTC, European Organization for the Research and Treatment of Cancer; NCCN, National Comprehensive Cancer Network; CMT, combination modality therapy; RT, radiation therapy; escBEACOPP, escalated bleomycin, etoposide, doxorubicin, cyclophosphamide, vincristine, procarbazine, prednisone; ABVD, doxorubicin, bleomycin, vinblastine, dacarbazine; Rx, treatment.