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Schematic illustration of the supramolecular network formation (not to scale). Interactions between the collagenous fibrillar structures and the aggrecan matrix are mediated by the perifibrillar adapter proteins matrilin-1, -3, and -4,17 decorin,13 COMP,9 and collagen IX.8 The adapter molecules interconnect collagen II/XI fibrils and link them to collagen VI microfibrils70 or aggrecan.13,16 Modified from Klatt et al.17 Abbreviation: COMP, cartilage oligomeric matrix protein.
