Table 1.
Summary of outcome measures across all experiments.
| Normothermia | Hypothermia | |||||||
|---|---|---|---|---|---|---|---|---|
| (a) Experiment 1 | ||||||||
| Occlusion duration (min) | 90 | 90 | ||||||
| n | 6 | 6 | ||||||
| Weight at MCAo (g) | 314 ± 18 | 321 ± 13 | ||||||
| Rectal temperature at MCAo (℃) | 37.6 ± 0.2 | 37.5 ± 0.2 | ||||||
| CBF decrement at occlusion (% of baseline) | 69.5 ± 13.0 | 72.7 ± 18.6 | ||||||
| CBF increment at reperfusion (% of pre-occlusion) | 155.6 ± 85.2 | 134.7 ± 57.6 | ||||||
| Behavioural deficit at 24 h (median (Q1–Q3)) | 1.5 (0.8–2.3) | 0.25 (0–1.6) | ||||||
| Infarct volume at 24 h | ||||||||
| Uncorrected (mm3) | 156.3 ± 65.8 | 56.8 ± 50.4* | ||||||
| Corrected for oedema (mm3) | 139.6 ± 56.8 | 52.2 ± 47.8* | ||||||
| Per cent of contralateral hemisphere | 22.7 ± 9.5 | 8.3 ± 6.6% * | ||||||
| (b) Experiment 2 | ||||||||
| Occlusion duration (min) | 90 | 90 | ||||||
| n | 10 | 10 | ||||||
| Weight at MCAo (g) | 329 ± 23 | 350 ± 28 | ||||||
| Rectal temperature at MCAo (℃) | 36.7 ± 1.0 | 36.4 ± 1.1 | ||||||
| CBF decrement at occlusion (% of baseline) | 84.3 ± 11.5 | 82.3 ± 11.7 | ||||||
| CBF increment at reperfusion (% of pre-occlusion) | 107.7 ± 35.0 | 95.3 ± 30.2 | ||||||
| Behavioural deficit at 24 h (median (Q1–Q3)) | 1.8 (0.6–2.0) | 1.5 (1.1–2.0) | ||||||
| Infarct volume at 24 h | ||||||||
| Uncorrected (mm3) | 221.2 ± 62.1 | 183.8 ± 99.7 | ||||||
| Corrected for oedema (mm3) | 195.6 ± 52.5 | 155.8 ± 77.4 | ||||||
| Per cent of contralateral hemisphere | 27.3 ± 6.2 | 23.1 ± 12.4 | ||||||
| (c) Experiment 3 | ||||||||
| Occlusion duration (min) | 60 | 75 | 90 | 120 | 60 | 75 | 90 | 120 |
| n | 31 | 32 | 34 | 31 | 31 | 32 | 31 | 32 |
| Weight at MCAo (g) | 308 ± 19 | 312 ± 19 | 310 ± 16 | 313 ± 13 | 310 ± 20 | 308 ± 23 | 315 ± 15 | 312 ± 22 |
| Rectal temperature at MCAo (℃) | 37.1 ± 0.5 | 37.3 ± 0.6 | 37.0 ± 0.6 | 37.1 ± 0.6 | 37.2 ± 0.7 | 37.0 ± 0.6 | 37.1 ± 0.6 | 37.2 ± 0.9 |
| CBF decrement at occlusion (% of baseline) | 66.6 ± 19.6 | 65.7 ± 17.6 | 68.3 ± 16.4 | 67.3 ± 15.5 | 57.5 ± 30.8 | 63.6 ± 19.1 | 61.8 ± 17.8 | 58.2 ± 23.4 |
| CBF increment at reperfusion (% of pre-occlusion) | 123.3 ± 56.5 | 135.1 ± 44.7 | 141.1 ± 76.3 | 150.6 ± 91.6 | 144.3 ± 68.5 | 157.8 ± 50.1 | 162.7 ± 67.4 | 137.5 ± 63.3 |
| Behavioural deficit at 24 h (median (Q1–Q3)) | 1 (0.3–2) | 1 (0.5–2) | 1.5 (0.6–2) | 1.3 (0.6–1.5) | 0 (0–0.5) | 0.5 (0–1) | 0.5 (0–1.5) | 1 (0.5–2) |
| Infarct volume at 24 h | ||||||||
| Uncorrected (mm3) | 143.3 ± 80.4 | 209.0 ± 81.1 | 247.2 ± 113.7 | 263.8 ± 89.5 | 67.3 ± 64.6* | 92.2 ± 64.6* | 152.7 ± 91.5* | 188.7 ± 88.6* |
| Corrected for oedema (mm3) | 134.2 ± 75.6 | 190.3 ± 38.9 | 218.9 ± 97.4 | 229.8 ± 76.8 | 64.7 ± 66.1* | 85.4 ± 58.1* | 137.5 ± 79.8* | 171.5 ± 79.1 |
| Per cent of contralateral hemisphere | 15.9 ± 8.9 | 23.4 ± 9.2 | 26.5 ± 11.6 | 28.2 ± 9.7 | 8.0 ± 8.2* | 10.4 ± 7.2* | 16.7 ± 9.9* | 20.7 ± 9.5* |
CBF: cerebral blood flow; MCAo: middle cerebral artery occlusion.
All values mean ± standard deviation (except behavioural deficit: median (Q1–Q3)); *p < 0.05.