Skip to main content
. Author manuscript; available in PMC: 2018 Mar 20.
Published in final edited form as: Nature. 2017 Sep 20;549(7673):548–552. doi: 10.1038/nature24023

Extended data Figure 2. Chromatid-type fusions induced by CYREN depletion in IMR90 fibroblasts.

Extended data Figure 2

a, Western blot showing TRF2 depletion. For gel source data, see Supplementary Figure 1. b, qRT-PCR measurement of CYREN isoforms expression after siRNA knock-down. Normalized to ACTB qRT-PCR. CYREN-1, PCR primers target mRNA transcript variant 1. CYREN-2, PCR primers target mRNA transcript variants 2, 3, 4 and 5. CYREN-3, PCR primers target mRNA transcript variant 7. c, Representative images of partial metaphase spreads of functional (shControl) and deprotected (shTRF2) telomeres after CYREN depletion. d, Mean percentage of fused chromosome ends per metaphase. Error bars, s.e.m. **P<0.01. One-way ANOVA, Sidak’s multiple comparison test. n: number of metaphases analysed.