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. Author manuscript; available in PMC: 2018 Feb 1.
Published in final edited form as: Curr Opin Syst Biol. 2016 Dec 14;1:95–101. doi: 10.1016/j.coisb.2016.12.007

Figure 3. The topology of evolution.

Figure 3

(a) Persistence diagram computed from an avian influenza dataset. The distributions of birth and death times (the positions of the two end points of each interval in the barcode) are shown. Their bimodality indicates two scales of topological structure, corresponding to intra-subtype (involving one HA subtype) and inter-subtype (involving multiple HA subtypes) viral reassortments. Figure adapted from [30] with permission of the authors. (b) Position-dependent recombination rate for a region in human chromosome 1, according to the topological maps of human recombination developed in [9]. Peaks correspond to recombination hotspots. Map based on 89 individuals from the British and Scotland (GBR) population sequenced by 1,000 Genomes Project [47].