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Extent of modification of (a) HC from free Fab-1 (red bars) compared to VEGF-bound Fab-1 (blue bars) and (b) LC from free Fab-1 (red bars) compared to VEGF-bound Fab-1 (blue bars) at residue level (data in triplicate). Residues with significant differences (p < 0.05) between the two states are shown with red asterisks.
