Table 2.

Clinical severity of individual symptoms assessed in the skin areas treated with study medication (patients with available data)

Disease symptoms	Clinical Severity score
	Baseline	Final visit
	Median (range)	Median (range)
Acne vulgaris
Erythema	3.0 (2–4)	2.0 (1–3)
Papules	3.0 (2–5)	2.0 (1–4)
Comedones	2.0 (1–4)	2.0 (1–3)
Pustules	2.0 (1–4)	1.0 (1–3)
Telangiectasia	1.0 (1–2)	1.0 (1–2)
Seborrhoea	2.0 (1–4)	2.0 (1–3)
Atopic dermatitis
Erythema	3.0 (2–4)	2.0 (2–4)
Induration	3.0 (2–4)	3.0 (1–4)
Excoriation	3.0 (2–4)	2.0 (1–4)
Lichenification	3.0 (2–4)	3.0 (2–4)
Exudation	2.0 (1–3)	1.0 (1–2)
Itching	3.0 (2–4)	2.0 (1–5)
Impetigo contagiosa
Erythema	3.4 (1–4)	2.0 (1–3)
Pustulation	2.5 (1–5)	1.0 (1–3)
Erosion	3.5 (2–5)	2.0 (1–4)
Crusts	4.0 (1–5)	2.0 (1–4)
Exudation	2.0 (2–4)	2.0 (1–3)
Rosacea
Erythema	4.0 (1–4)	3.0 (1–3)
Papules	3.5 (2–4)	3.0 (1–4)
Pustules	3.0 (2–4)	1.5 (1–3)
Telangiectasia	2.0 (1–3)	2.0 (1–2)
Seborrhea	2.0 (2–3)	2.0 (2–2)

Notes: Clinical Severity scores were rated on a five-point numerical analog scale (1=not at all to 5= very strongly)