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. 2017 Oct 2;12(10):e0185794. doi: 10.1371/journal.pone.0185794

Table 2. Phenotype probabilities for KD and activation (O) of node Mdm2 according to DNA damage S.

phenotype KD O
S 0 1 2 0 1 2
proliferation 1.0 0.0 0.0 0.0 0.0 0.0
apoptosis 0.0 1.0 0.45 0.0 0.0 0.0
senescence 0.0 0.0 0.55 0.0 0.0 1.0
transient arrest 0.0 0.0 0.0 1.0 1.0 0.0

For S = 2 and Mdm2 KD there is bistability between apoptosis and senescence.