Table 4. Mutations found in the DNA gyrase genes in 62 Salmonella enterica serovar Typhi isolates and 21 Salmonella enterica serovar Paratyphi A isolates.
| Serovar | Resistance phenotype | MIC-value ciprofloxacin (mg/L) | gyrA | gyrB |
|---|---|---|---|---|
|
Salmonella Typhi (n = 62) |
NaR, PefR, DCS | 0.19–0.38 | Ser83Phe (n = 60) | - |
| NaR, PefR, DCS | 0.38 | Asp87Asn + Ser83Phe (n = 1) | - | |
| NaI, PefR, DCS | 0.094 | - | Ser464Phe (n = 1) | |
|
Salmonella Paratyphi A (n = 21) |
NaR, PefR, DCS | 0.25–0.38 | Ser83Phe (n = 20) | - |
| NaR, PefR, DCS | 0.125 | Asp87Gly (n = 1) | - |
NaR = Nalidixic acid resistant. NaI = Nalidixic acid intermediate susceptible. PefR = Pefloxacin resistant. DCS = Decreased Ciprofloxacin Susceptibility. MIC = Minimum Inhibitory Concentration.