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. 2017 Feb 23;8(1):1–6. doi: 10.14740/wjon996w

Table 2. RIM After Radiotherapy for Breast Cancer.

Studies Site of radiation induced malignancy after radiotherapy for breast cancer Comment
Deutsch et al [21] Lung (ipsilateral and contralateral) Higher dose of radiotherapy to lung in breast cancer patients of NSABP 04 in comparison to NSABP 06 trial was associated with increased incidence of subsequent RIM in both ipsilateral and contralateral lung.
Boice et al [22] Contralateral breast The average radiation dose to the contralateral breast in this study was 2.82 Gy and less than 3% of radiation-induced breast cancer could be attributed to previous radiotherapy.
Zablotska et al [23] Esophagus (squamous cell carcinoma (SCC)) Increases the risk of SCC not adenocarcinoma. As upper and middle third esophagus (commonest site of SCC) not the lower third (commonest site of adenocarcinoma) comes in the radiation portal.
Kirova et al [24] Sarcomas Thirty-five out of 16,705 patients of breast cancer developed sarcomas (13 sarcomas were located in the breast, five in the chest wall, three in the sternum, two in the supraclavicular area, one in the scapula, and three in the axilla).