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. Author manuscript; available in PMC: 2018 Jun 1.
Published in final edited form as: J Pharm Innov. 2017 Mar 3;12(2):142–154. doi: 10.1007/s12247-017-9274-0

Fig. 1.

Fig. 1

Ternary phase diagram of PEG 400, propylene glycol, and glycerin, aiming to optimize the ratio among the three cosolvents in terms of CSIC solubility. Any point within the triangle represents a given composition of the three cosolvents. Outward arrows from each solvent matrix are drawn parallel to the sides of the triangle. The distances AB′, B′C″ and C″A indicate the parts of PEG 400, propylene glycol, and glycerin, respectively. For example, in the case of solvent matrix (S8), the matrix was composed of 75 parts of A, 50′ parts of B′ and 75″ parts of C″, and the ratio among A, B′ and C″ was 75:50:75, or 3:2:3 (w/w/w)