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. 2017 Oct;58(11):4826–4835. doi: 10.1167/iovs.17-22168

Figure 1.

Figure 1

Breathing NO gas lowers IOP in WT but not GC-1−/− mice. (A) Breathing 40 ppm NO (n = 10, ***P < 0.001), but not control gas (n = 10, P = 0.11), lowered IOP in anesthetized WT mice. (B) In contrast, breathing 40 ppm NO did not lower IOP in anesthetized GC-1−/− mice (n = 9, P = 0.08). (C–D) Breathing control gas did not affect IOP in awake WT (n = 7, P = 0.06) or GC-1−/− mice (n = 11, P = 0.93). Breathing 40 ppm NO for 40 minutes lowered IOP in awake WT mice (n = 7, ***P < 0.001) but not in awake GC-1−/− mice (n = 11, P = 0.20). BL, baseline.