. Author manuscript; available in PMC: 2018 Dec 1.

Published in final edited form as: J Magn Reson Imaging. 2017 Apr 3;46(6):1748–1759. doi: 10.1002/jmri.25712

Table 2.

Summary of MR imaging metrics with significant differences in nuclear grades and HER2 amplification of DCIS.

	Mean value ± standard deviation			Mean value ± standard deviation
Metrics	Non-HNG	HNG	p value	HER2−	HER2+	p value
Minimum intensity
Pre	117.2±137.2	152.9±163.3	0.396	155.9±156.7	45.6±52.3	0.039
4^th Post	468±402.8	568.9±423.3	0.338	561.2±417.7	282.5±315.1	0.050
Maximum intensity
Sub 1^st Post	573.0±413.3	629.4±513.2	0.593	648.1±452.6	365.5±330.8	0.048
Mean intensity
1^st Post	618.0±488.9	763.6±529.1	0.423	748.7±520.9	384.1±376.7	0.047
Median intensity
1^st Post	618.5±489.7	752.1±518.1	0.464	747.6±519.8	380.8±374.1	0.047
Sub 1^st Post	261.6±235.5	283.3±254.6	0.905	312.8±257.9	158.4±172.9	0.048
Percentage enhancement (based on Mean intensity)
1^st Post	80.60±35.92	79.72±24.42	0.768	81.54±34.88	74.47±14.03	0.629
4^th Post	130.7±52.8	127.4±26.5	0.550	127.4±45.8	133.1±29.5	0.447
Range
Sub 1^st Post	525.8±355.2	570.2±459.3	0.605	581.3±385.7	327.8±271.7	0.044
Mean deviation
1^st Post	120.2±82.9	147.1±122.6	0.873	142.3±103.8	72.4±71.2	0.028
Sub 1^st Post	86.4±59.2	94.59±88.63	0.539	98.4±70.1	50.2±45.5	0.022
Root mean square
1^st Post	637.0±497.2	786.4±546.3	0.423	771.0±532.6	394.9±386.5	0.047
Standard deviation
1^st Post	147.9±101.5	181.1±145.8	0.900	175.0±124.8	90.2±88.4	0.022
Sub 1^st Post	104.6±70.8	116.4±104.8	0.619	119.4±83.3	63.2±58.6	0.031
Skewness
Sub 1^st Post	0.347±0.500	0.499±0.624	0.240	0.272±0.288	0.496±0.279	0.031
Kurtosis
Sub 1^st Post	−0.081±1.448	0.440±2.744	0.121	−0.368±0.600	0.028±0.394	0.016
Variance
1^st Post	31749±34150	53363±77983	0.900	45759±64973	15176±28067	0.022
Sub 1^st Post	15753±18349	24188±40573	0.619	20986±26669	7087±11980	0.031
Surface : Volume ratio
Pre	2.483±0.606	2.100±0.613	0.027	2.322±0.571	2.299±0.526	0.080
1^st Post	2.482±0.607	2.098±0.614	0.026	2.321±0.571	2.291±0.532	0.080
4^th Post	2.481±0.607	2.098±0.614	0.026	2.321±0.571	2.291±0.532	0.080
Sub 1^st Post	2.643±0.780	2.183±0.608	0.032	2.399±0.607	2.301±0.525	0.085
Homogeneity 1
Pre	184.4±578.4	121.8±391.8	0.341	130.9±489.6	302.2±667.3	0.047
Homogeneity 2
Pre	82.0±248.6	63.1±216.2	0.423	57.43±210.5	163.8±370.3	0.038
Inverse variance
Pre	86.2±260.5	66.0±224.7	0.395	60.68±220.6	170.3±385.1	0.041
Short run emphasis (SRE)
Pre	0.841±0.117	0.819±0.113	0.528	0.846±0.111	0.750±0.098	0.022
1^st Post	0.843±0.116	0.823±0.112	0.608	0.848±0.112	0.758±0.094	0.041
4^th Post	0.842±0.116	0.823±0.112	0.608	0.847±0.111	0.757±0.095	0.044
Sub 1^st Post	0.839±0.121	0.819±0.115	0.550	0.846±0.111	0.757±0.095	0.044
Sub 4^th Post	0.840±0.118	0.819±0.114	0.573	0.846±0.111	0.756±0.095	0.041
Gray-level non-uniformity (GLN)
Sub 1^st Post	31.8±121.4	18.3±45.7	0.395	22.91±102.3	28.40±56.13	0.047
Long run low gray-level run emphasis (LRLGLE)
Sub 4^th Post	0.782±1.319	0.640±1.527	0.668	0.601±1.168	1.523±2.475	0.019