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. Author manuscript; available in PMC: 2018 Oct 2.
Published in final edited form as: Chem Soc Rev. 2017 Oct 2;46(19):5771–5804. doi: 10.1039/c7cs00195a

Fig. 15.

Fig. 15

(A) The structures of PTA, RAPTA-C, RAPTA-T and RAPTA-B. (B) Growth curve of A2780 tumors with respect to RAPTA-C treatment. (C) Images show representative tumors from the vehicle treated (CTRL) and RAPTA-C (0.2 mg kg-1) treated CAMs. (D) Representative images of the immunohistochemical staining of the endothelial cell marker CD31 (in brown) showing reduced microvessel density per mm2 in tumors treated with RAPTA-C normalized to the tumor surface area and provided as a % of the control (E) and Ki-67 positive nuclei (in blue) (D) and quantification of the percentage of the tumor surface area staining positive for Ki-67 (as a % of CTRL) (F). Black bar in the right image of (D) represents 500 mm and is valid for both images. Reproduced with permission from ref. 168. Copyright 2012, Royal Society of Chemistry.