Table 2.
The cytotoxicity of the selective polypyridyl Ru(II)complexes used in PDT
| Compounds | Cell lines | Dark IC50 (μM) |
light IC50 (μM) |
PIa | Irradiation Wavelength (nm) |
Mechanismb | Ref. |
|---|---|---|---|---|---|---|---|
| 14b | HeLa | 334 | 0.47 | 1110 | 466 | A+B | 243 |
| 14c | A431 | 13 | 0.6 | 22 | 520 | A | 244 |
| 14d | A431 | 38 | 7.8 | 4.9 | 520 | A | 244 |
| 14f | HL60 | > 300 | 1.6 | > 188 | VLd (> 450) | A | 246 |
| 14g | HL60 | 108 | 2.6 | 42 | VL (> 450) | A | 246 |
| 14h | HL60 | 52.5 | 1.2 | 43.8 | Blue light | A | 247 |
| 14i | HL60 | 47.3 | 2.4 | 19.7 | Blue light | A | 247 |
| 14j | HL60 | 34 | 0.65 | 52 | VL (400) | A | 248 |
| 14k | HL60 | > 300 | 0.16 | 1880 | VL (400) | A | 248 |
| 14n | HeLa | 49.7 | 0.62 | 80 | 420 | B | 253 |
| 14o | HeLa | > 100 | 25.3 | > 4 | 420 | B | 254 |
| 14p | HeLa | > 100 | 20 | 5 | UVe | B | 254 |
| 14q | HeLa | 70 | 8.8 | 8 | VL | B | 255 |
| 14r | A549 | 19 | 0.72 | 26 | 454 | A+B | 256 |
| 14s | HL60 | 262 | 0.15 | 1747 | White light | B | 258 |
| 14u-I | HL60 | > 300 | > 300 | Nc | VL | B | 1 |
| 14u-III | HL60 | > 300 | 16 | > 20 | VL | B | 1 |
| 14v | HL60 | 135 | 34 | 4 | 625 | B | 261 |
| 14X | HL60 | > 300 | 0.741 | > 410 | VL | B | 262 |
| 15a | HeLa | > 100 | 1.9 | > 52 | 800 | B | 264 |
| 15b | HeLa | > 500 | 5.71 | 19 | 810 | B | 98 |
| 15c | HeLa | > 100 | 1.9 | 250 | 800 | B | 265 |
a
PI means IC50(dark)/IC50(light).
b
the ways of producing phototoxicity; A means ligand dissociation, B means ROS/1O2.
c
N means not.
d
VL means visible light.
e
UV means ultraviolet.