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. Author manuscript; available in PMC: 2018 Oct 2.
Published in final edited form as: Mol Pharm. 2017 Sep 18;14(10):3269–3280. doi: 10.1021/acs.molpharmaceut.7b00322

Figure 4. Histidine lowers −18 sfGFP viscosity by charge shielding.

Figure 4

A, The relative viscosity in high trehalose-high salt buffer (10 mM histidine pH 5.8, 660 mM trehalose and 210 mM NaCl); B, the relative viscosity in high salt (10 mM histidine pH 5.8 and 210 mM NaCl); and C, the absolute viscosity in high salt buffer is shown as solid black icons with black dashed lines to guide the eye. High cosolute data with the modified Mooney fit from Figure 1B is shown for reference in hollow red icons.