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. Author manuscript; available in PMC: 2018 Oct 2.
Published in final edited form as: Mol Pharm. 2017 Sep 6;14(10):3239–3247. doi: 10.1021/acs.molpharmaceut.7b00216

Figure 4.

Figure 4

Analysis of whole lung average signal and maximum lung signal derived from ROI quantification of PET images. Signal in the whole lung of H460-bearing mice increased from 4 to 24 h post-injection. The maximum lung signal corresponded to the highest signal found in a single tumor nodule. H460 tumor-bearing mice showed significantly higher maximum and average lung uptake compared to their H358 counterparts. The non-specific IgG showed high initial uptake in both whole lung and maximum lung values, yet both rapidly declined by 48 h post-injection. Results were expressed as %ID/g (mean ± SD) with n=4. * p-value ≤ 0.05, ** p-value ≤ 0.01.