Table 3.

Estimated magnitudes and habituation of N1, N2P2 and pain scores by phase

	N1 (μV)		N2P2 (μV)		Pain scores
	Coef.	95% CI	Coef.	95% CI	Coef.	95% CI
Main effects
Preictal	0.939	[−0.476, 2.353]	1.342	[−1.993, 4.677]	−0.01	[−0.36, 0.34]
Ictal	−0.641	[−1.753, 0.470]	1.088	[−2.862, 5.039]	0.23	[−0.28, 0.74]
Postictal	0.839	[−0.487, 2.166]	2.426	[−2.419, 7.272]	0.37	[−0.35, 1.10]
Habituation	−0.653*	[−1.315, −0.001]	−3.623***	[−5.147, −2.098]	0.21***	[0.09, 0.33]
Interaction effects
Preictal × Habituation	−0.868	[−2.283, 0.547]	−0.497	[−3.445, 2.451]	0.07	[−0.10, 0.24]
Ictal × Habituation	0.293	[−0.746, 1.331]	−0.455	[−4.086, 3.176]	0.06	[−0.18, 0.31]
Postictal × Habituation	−1.070	[−2.890, 0.749]	0.726	[−3.657, 5.108]	0.12	[−0.17, 0.41]
Constant	6.088	[5.186, 6.989]	36.783	[33.002, 40.565]	4.11	[3.56, 4.67]

The constant represents interictal first-block or mean pain score responses, the first three main effects are first-block amplitude or pain score differences from the interictal phase and the fourth “Habituation” main effect is the difference between first and second block, or the linear change of pain scores, in the interictal phase. The interaction effects represent habituation differences between the interictal phase and the preictal, ictal and postictal phases, respectively. Thus, the significant coefficients are interpreted as decreased second-block N1 and N2P2-amplitudes, and linear increase in pain scores, in the interictal phase, i.e. interictal N1 and N2P2 habituation and subjective pain sensitization. Lack of significant interaction effects are interpreted as no habituation differences between the interictal phase and the other phases. Random effects estimates are shown in Supplementary Table 2. * p < 0.05, ** p < 0.01, *** p < 0.001