Table 5.

Estimated magnitudes and habituation in migraineurs in the interictal phase and controls

	N1 (μV)		N2P2 (μV)		Pain scores
	Coef.	95% CI	Coef.	95% CI	Coef.	95% CI
Main effects
Migraine	−1.014	[−3.767, 1.739]	−2.395	[−10.707, 5.917]	0.60	[−0.32, 1.52]
Habituation	−0.374	[−1.527, 0.778]	−5.307***	[−9.232, −1.383]	0.10	[−0.06, 0.26]
Interaction effect
Migraine × Habituation	−0.268	[−1.875, 1.339]	−0.036	[−4.781, 4.854]	0.13	[−0.09, 0.35]
Constant	7.365	[5.070, 9.660]	39.382	[33.531, 45.234]	3.54	[3.01, 4.07]

The constant represents first-block amplitude or pain score responses in controls. The main effect of migraine represents the first-block amplitude or pain score difference between groups. The main effect of habituation represents the difference between first and second block amplitudes, or linear change in pain scores, in the control group. The interaction effect represents the habituation-difference between groups. Thus, the significant coefficient is interpreted as N2P2 habituation in the control group. The corresponding interaction effect is not significant, indicating no difference in habituation between controls and migraineurs in the interictal phase. Random effects estimates are shown in Supplementary Table 3. * p < 0.05, ** p < 0.01, *** p < 0.001