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. 2017 Oct 2;7:12504. doi: 10.1038/s41598-017-12249-y

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© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Expression of miRNAs and their target transcripts. Image (a) shows the DEMs abundance change in RNA-seq analysis with AHO treatment. Image (b) represents the potential regulation between miRNAs and their target genes. The T shape end and arrow represent the opposite or same regulation trend between miRNA and mRNA. Image (c) shows the DEGs level in RNA-seq analysis. Image (d) and (e) shows the relative expression levels of miRNA and mRNA transcript assessed by qRT-PCR, respectively. The relative level of qRT-PCR calculated by the delta-delta-CT method. Data is presented as mean ± standard error.