Fig. 1.

CNTNAP2 expression in excitatory neurons induced from family trio. a By qPCR, CNTNAP2 expression is significantly increased in Ngn2-induced neurons compared to neural progenitor cells (NPCs) and hiPSC-derived astrocytes. Data reflects biological triplicate samples from one hiPSC line derived from each of three healthy controls (mean +/− s.e.m). b RNA sequencing data shows total CNTNAP2 expression is increased in deletion carriers compared with non-carrier control (mean +/− s.e.m). c Genes differentially expressed in CNTNAP2 deletion carriers are enriched for genes involved in DNA binding and central nervous system development. * p < 0.05, *** p < 0.001