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. 2017 Oct 2;7:12490. doi: 10.1038/s41598-017-11976-6

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© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Functional evaluation of the CPC secretome. (a) CPC wound healing capacity. All CPC isolates (CPC1-3) showed enhanced repair capacity compared with HDF cells; expressed as the percentage of scratch closure. (b) HDF cells in CM from the three CPC isolates showed improved repair capacity compared with the negative control (DMEM); expressed as percentage of closure. (c,d) Angiogenic activity in CM from the three CPC isolates compared with negative (C+) and positive controls (C+), using HUVEC (see Methods); after 6 h incubation, tube formation was analyzed using ImageJ software. Bar, 500 μm. Data are expressed as mean ± SD; n = 3.