. 2017 Oct 2;8:762. doi: 10.1038/s41467-017-00736-9

Table 3.

Cross-reactivity of neutralizing monoclonal antibodies against escape mutants

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NT, neutralization

^aNeutralizing antibodies are assembled into five subgroups according to the cross-neutralization of EV71 12-96015 and 11-96023 escape mutants: canyon northern rim (16-2-11B, 16-2-2D, 16-3-3C) (red), canyon floor (16-2-8C, 16-2-9D, 16-2-12D) (green), canyon southern rim (17-2-2B, 16-3-10B) (blue), 3-fold plateau (16-3-4D, 34-1-6D) (cyan) and 2-fold plateau (17-1-12A, 17-2-12A) (orange)

Inline graphic : Complete loss of neutralization; : More than 8-fold decrease of NT titer; −: maintenance of neutralization