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. 2017 Oct 2;7:12528. doi: 10.1038/s41598-017-13065-0

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© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Brain areas where changes in the BOLD response to SS after CBT-I correlated significantly with clinical improvement in insomnia after CBT-I. 1: Left superior paracentral cortex. 2: Left inferior paracentral cortex. 3: Right insula. (A) Decrease in WASO after CBT-I was correlated with a reduction in the left superior paracentral BOLD response to SS. (B) DBAS score decrease after CBT-I correlated with a decrease in the left inferior paracentral BOLD response to SS. (C) WASO decrease after CBT-I correlated with a decrease in the right insular BOLD response to SS. Note: The BOLD response to SS was calculated by subtraction of the BOLD response to NS from the BOLD response to SS (SS-NS).