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. 2017 Oct 2;7:12488. doi: 10.1038/s41598-017-12624-9

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© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Liver oxylipins correlate with soybean oil-induced obesity. (a) Correlation between body weight and concentration of liver oxylipins of individual mice. Spearman correlation coefficient (r) is 0.8 for 9,10-DiHODE (P = 0.0007), 0.8 for 12,13-DiHODE (P = 0.0009), 15,16-DiHODE (P = 0.0009), 0.6 for 12,13-DiHOME (P = 0.02) and 0.5 for 9,10-DiHOME (P = 0.06). Goodness of fit or R² values for linear regression are indicated on the graphs. (The Viv group was not included in the correlation analyses in Supplementary Fig. S4a,b,c). (b) Absolute levels of oxylipins that correlate only in liver (hatched bars). Values in plasma (solid bars) are shown as a comparison. N = 4–5 mice per group. ^aSignificantly different (within same tissue) from all others, ^bfrom CO and Viv, ^cfrom Viv, ^dfrom CO, ^ffrom PL + CO. The fatty acid from which the oxylipin was derived is shown in parentheses. Data are presented as ± SEM.