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. 2017 Oct 2;7:12488. doi: 10.1038/s41598-017-12624-9

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© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Alterations in LA-, ALA- and AA-metabolizing enzymes in SO + CO versus PL + CO livers correlate with oxylipin and prostaglandin levels. (a) Integrated proteomic-metabolomic network analysis comparing PL + CO and SO + CO livers based on significant metabolites/proteins (black borders) (pFDR < 0.05) and their connecting nodes. Node colors: red, up in PL + CO; green, up in SO + CO; white, no change; gray, no data mapped to nodes. (b) Left, absolute levels of EPOMEs and EPODEs shown in (a) (one outlier mouse in the PL + CO group was removed). Right, Correlation between body weight and concentration of liver epoxides of individual mice. Spearman correlation coefficient (r) is 0.6 for 9,10-EpODE (P = 0.02) and 15,16-EpODE (P = 0.03), 0.5 for 12,13-EpOME (P = 0.07) and 9,10-EpOME (P = 0.08). Goodness of fit or R² values for linear regression are indicated on the graphs. c) Levels of arachidonic acid (AA) and prostaglandins in liver. N = 4–5 mice per group. *Significantly different (P < 0.05). Data are presented as ± SEM (b and c).