Table 1.

Plausible target profiling of drug scaffold 1 resulting from 2D-similarity based chemocentric network, CSNAP.

No.	Representative Structures	ChEMBL_ID	Target Protein	CTD Gene Symbol	Max T	Frequency
1		CHEMBL105049	Brain glycogen phosphorylase	PYGB	0.635	5
2		CHEMBL1095750	Metabotropic glutamate receptor 2	GRM2	0.618	2
3		CHEMBL1221817	Histone deacetylase	HDA	0.617	2
4		CHEMBL15153	Histamine H1/H2/H3 receptor, Histamine N-methyltransferase	HRH, HNMT	0.680	4
5		CHEMBL1800404	Isoprenylcysteine carboxyl methyltransferase	ICMT	0.692	16
6		CHEMBL1822855	HERG, Histamine H3 receptor	KCNH, HRH3	0.667	4
7		CHEMBL2430315	Sodium/glucose cotransporter 2	SLC5A2	0.623	1
8		CHEMBL262464	Human immunodeficiency virus type 1 protease	POL	0.623	4
9		CHEMBL271392	Peroxisome proliferator-activated receptor α, δ, γ	PPAR	0.646	5
10		CHEMBL33295	Monoamine oxidase A	MAOA	0.623	2
11		CHEMBL352737	Dipeptidyl peptidase II, IV, Prolyl endopeptidase	DPF, PREP	0.603	2
12		CHEMBL477276	Leukotriene A4 hydrolase	LTA4H	0.600	2
13		CHEMBL479623	Neuronal acetylcholine receptor protein alpha-4/7/3 subunit	CHRNA	0.609	1
14		CHEMBL495707	Oestrogen receptors α and β	ESR	0.600	1
15		CHEMBL52167	Serotonin 4 (5-HT4) receptor	HTR4	0.660	9
16		CHEMBL66093	Coagulation factor X	F10	0.645	2