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. 2017 Oct 2;7:12512. doi: 10.1038/s41598-017-12627-6

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© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Loss of normal distribution in V/J pairing is associated with the SjS^S mouse. Total salivary gland T-lymphocyte three dimensional histograms of TCR gene V/(D)J combinations for B6 TRA (upper left) and B6 TRB (upper right) genes, as well as B6.NOD-Aec1/2 TRA (lower left) and TRB (lower right) genes. Blue bars indicate data from male mice, pink from female mice, and hybrid blue-pink bars for data shared between the sexes. The x-axis represents the analyzed Vα or Vβ gene segment, the z-axis is the analyzed Jα or D/Jβ gene segments, the height or y-axis indicates the total reads of specific V/(D)J combination. V and J genes were designated by the disambiguated IMGT nomenclature for each gene subgroup. TCR repertoire was quantified by entropy (E = Shannon’s Entropy) and diversity (D = Simpson’s Index).