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. 2017 Oct 2;7:12550. doi: 10.1038/s41598-017-13058-z

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© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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EO6-treatment reduced oxLDL-induced inflammation in Npc1 ^mut BMDMs. TNFα protein levels (A) and gene expression of inflammatory-related genes Tnfα and Ccr2 (B) after oxLDL loading of Npc1 ^mut BMDMs in absence or presence of anti-oxLDL EO6 antibodies. All data represent n = 3 (triplicates) for each experimental group. Asterisks indicate significant difference from non-immunized Npc1 ^wt-tp and Npc1 ^mut-tp mice by use of two-tailed unpaired t test. *p < 0.05; ***p < 0.001. All error bars are SEM.