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. 2017 Sep 28;8:1190. doi: 10.3389/fimmu.2017.01190

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Copyright © 2017 Selenius, Martelius, Pikkarainen, Siitonen, Mattila, Pietikäinen, Suomalainen, Aalto, Saarela, Einarsdottir, Järvinen, Färkkilä, Kere and Seppänen.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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B-cell phenotyping results (%) in probable and possible CVID patients. Abbreviations: B⁻, CD19⁺ B cells ≤1% of lymphocytes; smB⁻, switched memory B cells ≤2% of B cells; 21low, CD21^low cells ≥10% of B cells; Tr-high, transitional B cells ≥9% of B cells (in total, 129 CVID patients had B-cell phenotyping data available. Transitional B cells had been studied in 114 subjects). Asterisks mark statistical significance between “probable” and “possible CVID” patients, *p < 0.01 (χ²-test).