Table 3.
Deep brain stimulation with diffusion tensor imaging for obsessive–compulsive disorder.
| First author (ref) | Response | Scale | Mean preop, scores (range) | Mean postop, scores (range) | Mean improvement (%) | Target | Tract |
|---|---|---|---|---|---|---|---|
| Prospective direct tract targeting | |||||||
| Coenen (33) | 2 responders | Y-BOCS | 34.5 ± 6.4 (30–39) | 20.5 ± 7.8 (15–26) | 41.7 ± 11.79 | VC/VS | slMFB |
| Retrospective tract proximity analysis | |||||||
| Makris (34) | 1 responder | Y-BOCS | Not reported | Not reported | 35 | VC/VS | lOFC-thal mOFC-thal |
| Retrospective tract stimulation modeling | |||||||
| Hartmann (35) | 4 responders 2 non-responders |
Y-BOCS | Not reported | Not reported | 53.8 ± 27.9 15.8 ± 17.5 |
ALIC NAcc | – |
| Prospective cohort: | Retrospective cohort: | ||||||
| Overall responder proportion = 2 out of 2 (100%) | Overall responder proportion = 5 out of 7 (71%) | ||||||
| Overall mean improvement in responders = 41.7 ± 11.8% | Overall mean improvement in responders = 44.4 ± 27.9% | ||||||
| Overall mean improvement among non-responders = n.a. | Overall mean improvement among non-responders = 15.8 ± 17.5% | ||||||
Scale. Y-BOCS, Yale-Brown Obsessive–Compulsive Scale (55).
Targets. VC/VS, ventral anterior internal capsule and ventral striatum; ALIC, anterior limb of internal capsule; NAcc, nucleus accumbens.
Tract. l/mOFC-thal, lateral/medial orbitofrontocortical-thalamic.