Figure 2.

Sequence alignment of sFRPs and structural mode of Sizzled CRD. A, sequence alignment of X. laevis Sizzled and human sFRPs based on Sizzled structure with paired cysteines labeled by green numbers. The solvent accessibility (acc) of each Sizzled residue is presented from white to blue. The deeper blue means higher solvent accessibility. B, ribbon model of Sizzled CRD with secondary structure elements labeled. C, superimposition of X. laevis Sizzled (cyan), mouse Frizzled 8 (green), and mouse sFRP3 (pink) CRD ribbon models. Inter-helical loops are shown.