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Structural comparison of Sizzled and Frizzled8 CRD-XWnt8 complex. A, superimposition of ribbon models of Sizzled and Frizzled8 CRD-XWnt8 complex (PDB code 4F0A). B, overlay of XWnt8 index finger (purple)-binding site on mouse Frizzled8 CRD (green) with Sizzled CRD (cyan). C, overlay of XWnt8 thumb (purple)-binding site on mouse Frizzled8 CRD (green) with Sizzled CRD (cyan). The XWnt8 lipid group, PAM, is shown as red stick representation.
