Figure 7.

Effect of DPC on Na⁺, Fe²⁺, and Fe³⁺ uptake by PfCRT-expressing oocytes. A, uptake of sodium ions from an external concentration of 22 μm ²²Na and 5 mm unlabeled Na⁺ by water-injected oocytes and oocytes expressing PfCRT^HB3 or PfCRT^Dd2 in the presence (black bar) and absence (gray bar) of DPC (1 mm). The means ± S.E. (error bars) are shown of N_BR = 3 independent determinations. Statistical significance was assessed using the two-tailed t test. B, PfCRT-mediated Fe²⁺ (middle) and Fe³⁺ (right) by PfCRT^HB3- and PfCRT^Dd2-expressing oocytes in the presence (black bar) and absence (gray bar) of DPC (1 mm). Results are presented as means ± S.E. of N_BR = 4 independent determinations. n.s., not significant.