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. 2017 Aug 14;292(39):16221–16234. doi: 10.1074/jbc.M117.797746

Figure 2.

Figure 2.

Structure of the hMEX-3C KH domains in complex with RNA segments. A, schematic representation of the KH1–GUUUAG complex structure. In the left-hand panel, the KH1 domain is shown in cyan, and the MRE10b RNA (GUUUAG) is shown as a stick representation. The right-hand panel shows the electrostatic surface potential of the KH1–GUUUAG complex surface. The N-terminal helix of the KH1 domain is not an original component of KH domain architecture, and its formation may be induced by the addition of the expression tag. B, schematic representation of the KH2–CAGAGU complex structure. The left-hand panel shows the KH2 domain in magenta and the observable nucleotides of MRE10a (AGAGU) as sticks. The right-hand panel shows the electrostatic surface potential of the KH2–CAGAGU complex surface. Regions of electropositive and electronegative potential are shown in blue and red, respectively. The Fo − Fc maps before inclusion of RNAs are shown as green mesh (contoured at 2.0 σ), and the simulated annealing 2Fo − Fc composite omit maps are shown as purple mesh (contoured at 1.0 σ).