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The pH-controlled fibrillation of β-synuclein. The three domains of βS are indicated. The approximate location of two mutations associated with dementia (P123H and V70M) (1) are indicated with red stars. Segments predicted to be amyloidogenic according to the 3D-profile method (10) are indicated by green rectangles below the domains. AFM images shown for wild-type βS (boxed on the right) and its mutants are taken from Ref. 2.
