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Schematic presentation of oxidative stress modulation of cell migration via GSK-3β/PRMT4 signaling. GSK-3β phosphorylates T132 within PRMT4 to stabilize PRMT4 protein from ubiquitin proteasomal degradation. Oxidative stress downregulates GSK-3β, which leads to PRMT4 degradation. Decreased PRMT4 protein impedes cell migration, which may affect repair and regeneration process after lung injury.
