Fig. 2.

Activation of the Akt pathway is required for oxLDL-induced endothelial proliferation. A: representative Western blot image for oxLDL-induced Akt phosphorylation (50 µg/ml) with or without the presence of the Akt-specific inhibitor MK2206 (100n M); markers’ lane is shown at left. B: densitometric analysis of phosphorylated (p)-Akt/total Akt ratio in cells exposed to oxLDL (50 µg/ml) with or without the presence of MK2206. *P < 0.05, n ≥ 5. C: endothelial proliferation assayed by BrdU staining of HAECs exposed to oxLDL with or without Akt inhibitor MK2206 pretreatment. *P < 0.05, n ≥ 3.