BOO causes an increase in collagen expression in 12 days that is blocked by glyburide and anakinra. The groups are the same used in Fig. 1 and described in materials and methods. Results are the means ± SE; n = 6, 8, 5, 6, and 5, respectively. All groups were compared using a one-way ANOVA followed by a Student-Newman-Keuls post hoc test. Brackets above the graph indicate group comparisons and their level of significance. All groups were compared, and differences between any two groups not indicated by brackets were not significant. *P < 0.05, **P < 0.01.