Table 4.

General physiological data in ADX rats treated by spironolactone

	Vehicle		Spironolactone
	NK	HK	NK	HK
ΔBody weight, g	−15.6 ± 2.5	−38.4 ± 3.0**	8.2 ± 3.0###	−43.2 ± 5.5***
Food intake, g/24 h	16.2 ± 1.2	12.5 ± 0.8*	17.1 ± 1.0	12.2 ± 1.2*
Water intake, ml/24 h	42.4 ± 7.5	61.3 ± 1.4*	39.4 ± 5.4	65.6 ± 3.8*
Urine volume, ml/24 h	34.0 ± 1.7	46.2 ± 2.2*	27.5 ± 1.7#	53.8 ± 2.1*
Urine osmolality, mosmol/kg⋅H2O	1027.6 ± 59.1	1298.4 ± 76.0*	1485.2 ± 148.3#	1097.8 ± 55.6*
Plasma osmolality, mosmol/kg⋅H2O	307.2 ± 2.9	311.0 ± 2.3	309.6 ± 2.9	312.0 ± 1.1

Values are expressed as means ± SE.

^*P < 0.05 vs. NK.

^**P < 0.01 vs. NK.

^***P < 0.001 vs. NK.

^#P < 0.05 vs. Vehicle.

^###P < 0.001 vs. Vehicle.