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. 2017 Aug 15;58(10):2017–2036. doi: 10.1194/jlr.M078600

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Copyright © 2017 by the American Society for Biochemistry and Molecular Biology, Inc.

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Fig. 5. — The pathway of sterol biosynthesis in Cryptococcus. Based on the profile obtained for H99, R265, and R272, the pathway of sterol biosynthesis in Cryptococcus is composed of the following enzymatic steps: (1) squalene monooxygenase (Erg1), 2,3-oxidosqualene-lanosterol cyclase (Erg7); (2) lanosterol 14-α-demethylase (Erg11), C14 sterol reductase (Erg24), C4 methyl sterol oxidase (Erg25), C-3 sterol dehydrogenase (Erg26); (3) 3-keto sterol reductase (Erg27); (4) C24-sterol methyltransferase (Erg6); (5) C8-sterol isomerase (Erg2); (6) C5-sterol desaturase (Erg3); (7) C22-sterol desaturase (Erg5); (8) C24-sterol reductase (Erg4); (9) Erg6; (10, 11, 12)^£ Erg25, Erg26, Erg27 and Erg11; (13) Erg4; (14) Erg5, and (15) Erg3. “^£” represents putative enzymes involved in the step.