Table 2.

Short-circuit current and transepithelial conductance measured across isolated segments of distal ileum taken from wild-type and DRA-knockout mice following bilateral ion substitution of either Cl⁻ or $\mathit{H}\mathit{C}{\mathit{O}}_{\mathit{3}}^{\mathit{-}}$/CO₂

	Isc, μeq·cm−2·h−1		GT, mS/cm2
Genotype	Cl−-Free	$\mathrm{H}\mathrm{C}{\mathrm{O}}_3^{-}$/CO2-Free	Cl−-Free	$\mathrm{H}\mathrm{C}{\mathrm{O}}_3^{-}$/CO2-Free
WT	−1.87 ± 0.15 (14)	−2.16 ± 0.17 (12)	19.39 ± 0.95 (14)	29.82 ± 1.48 (12)
DRA-KO	−2.99 ± 0.32* (14)	−3.15 ± 0.55 (10)	18.96 ± 1.39 (14)	28.23 ± 1.56 (10)

Values are means ± SE with associated sample size in parentheses. I_sc, short-circuit current; G_T, transepithelial conductance; WT, wild type; KO, knockout.

^*Statistically significant difference between genotypes as determined by independent t-test (P ≤ 0.05).