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. 2017 Aug 24;5(5):e00334. doi: 10.1002/prp2.334

Table 1.

Weight ratios of the membrane‐permeable peptides in their conjugates (mice,iv injection. aa denotes the amino acid residue)

Dosage(mg kg−1) Survival rate (%) Molecular weight (Dalton) Weight of MPP in conjugates (%) References
GABA 8000 100 103 0
TD (11aa) 140 100 1065 100
TAT(11aa) 27 50 1560 100
CTP(11aa) 21 50 1558 100
R11(11aa) 16.5 50 1735 100
GABA –TD 100 100 1149 92.7
GABA –TAT 19 50 1645 94.8
GABA –CTP 13 50 1644 94.8
TAT –ChAT 339 50 70000 2.2
TAT –hEGF 0.1 100 7000 22.3 Zhao et al. (2011a)
TAT –BDNF 5 100 14400 10.8 Zhou et al. (2008);
TAT –tCNTF 1 100 21664 7.2 Qu et al. (2008)
TAT ‐P53 5 100 54000 2.9 Zhao et al. (2009); Zhao et al. (2011b)
TAT ‐TH 8 100 61000 2.6 Wu et al. (2006); Fu et al. (2006);
TAT –ChAT 4 100 70000 2.2 Fu et al. (2004, 2005)

MPP, membrane‐permeable peptides; GABA, γ‐aminobutyric acid.