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Relaxation of precontracted femoral artery. Relaxation of rat isolated femoral artery to ACT‐246475 (open circles) and ticagrelor (black circles). Rings of femoral artery were precontracted with 1 μmol/L U46619, and increasing concentrations of the two P2Y12 antagonists were added to the organ bath. Data are presented as means ± SEM, n = 4–6. **P < 0.01.
